In May 1934 there came under my observation a woman who,. on examination for a banal skin eruption, was found to have a peculiar whitish lesion of the mucous membrane of the mouth. Further investigation revealed a similar discoloration of the mucous membrane of the labia, the vaginal walls and the upper part of the anal canal and the rectum. One of the patient's two children, aged 13, the patient's mother, a brother, two sisters and a maternal aunt had the same "white mouth." The possibility of the development of a malignant process had been a source of considerable anxiety, especially as there was a history of cancer in the family. As I could not recall having seen a similar condition and as it seemed important to determine whether the changes were suggestive of a precancerous condition, I took a specimen of tissue from the mouth for biopsy. The report
CANNON AB. WHITE SPONGE NEVUS OF THE MUCOSA (NAEVUS SPONGIOSUS ALBUS MUCOSAE). Arch Derm Syphilol. 1935;31(3):365–370. doi:10.1001/archderm.1935.01460210076008
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