Colloidal sulphur was first prepared in 1888 by Debus.1 Sven Odén1a in 1911 made further extensive investigations of this product. Sulphur was frequently used for local application to the skin many years before dermatology became a recognized specialty. Colloidal sulphur, although it was first prepared more than forty-five years ago, has never been used to any appreciable extent.
Plant pathologists have found colloidal sulphur to be the most satisfactory form of sulphur to destroy fungous and animal parasites. They have manufactured it by many methods, but generally they find that it is too expensive to be used as a spray for plants. Colloidal sulphur has also been used intramuscularly and intravenously by neuropsychiatrists and internists in the treatment of certain diseases.
There are many opinions as to the mode of action of sulphur. Dermatologists have not been primarily concerned with the complicated chemical reactions that occur when it
MILLER HE. COLLOIDAL SULPHUR IN DERMATOLOGY. Arch Derm Syphilol. 1935;31(4):516–525. doi:10.1001/archderm.1935.01460220074008
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