Since the medical profession has taken cognizance of the large and increasing number of dermatoses of fungous origin, interest in their therapy has grown apace, further stimulated by the realization that as yet no highly specific drugs have been developed which yield even reasonably satisfactory results in all proved cases of fungous dermatitis. Continued study of the behavior of various drugs toward pathogenic fungi in the laboratory has served to increase the conviction that many factors other than the specific toxicity demonstrated in the test tube determine the clinical usefulness of a fungicide. Among such factors are included its tolerance by the human skin in concentrations permitting appreciable fungicidal action, its inactivation by various vehicles, the possibility of actual penetration of the chemically active substance to the layers of the epidermis which contain the actively growing organisms and its specificity or lack of toxicity for the species of fungus present.
WIEDER LM. FUNGISTATIC AND FUNGICIDAL EFFECTS OF TWO WOOD-PRESERVING CHEMICALS ON HUMAN DERMATOPHYTES: ORTHO (2 CHLOROPHENYL) PHENOL SODIUM AND TETRACHLORPHENOL SODIUM. Arch Derm Syphilol. 1935;31(5):644–657. doi:10.1001/archderm.1935.01460230031004
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