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The following case is interesting in many respects and subject to a great deal of speculation.
I was the patient, and consequently observations were made more frequently than is ordinarily possible.
Some Concord grapes were prepared for grape juice. About two thirds of a bushel were crushed by hand and squeezed through the fingers to break the skins. A number of the grapes were eaten during the process. After part of the grapes had been prepared, the skin on the back of the hands, wrists and forearms began to itch. Later the hands and arms were washed with soap and water to remove the juice and stains, but the skin continued to itch. Within twenty-four hours a red macular rash developed on the areas of itching. At this time some grape marmalade was eaten. The marmalade was prepared from grape skins which were pushed through a sieve and cooked for
ANDERSON JM. DERMATITIS FROM GRAPES. Arch Derm Syphilol. 1935;31(5):658–660. doi:10.1001/archderm.1935.01460230045005
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