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July 1935


Author Affiliations

Montreal, Canada.

Arch Derm Syphilol. 1935;32(1):108. doi:10.1001/archderm.1935.01470010111017

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To the Editor:—In view of the recent report in the Archives (30:843 [Dec.] 1934) by Prinzmetal on the use of nitrites for the relief of pruritus, it may be of interest to record the effect of erythrol tetranitrate on a patient with chronic pemphigus. The patient, a Jewish housewife, aged 43, had presented extensive bullous lesions characteristic of pemphigus vulgaris for nineteen months. The lesions had gradually extended until four months ago, when she was admitted to the Royal Victoria Hospital at Montreal. The eruption was generalized. The mucosae and the genitals were free from lesions. The Pels-Macht test was made, the result being 54 per cent. Severe toxemia was present.

A marked feature of the disease was an associated pruritus and burning. This gradually became more severe, until it was almost unbearable. Sleep was possible for her (and for the remainder of the patients in the ward)

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