It is generally assumed that the lesions of lymphogranuloma inguinale are limited to those of primary infection and local bubo.1 There are many observations on record,2 however, of fever, rigors, malaise, weakness, loss of weight and such rheumatoid manifestations as erythema nodosum, episcleritis, periarticular pains and polyarthritis, and some authors have therefore suggested that the disease may at times spread beyond the local lymphatic barrier. Frauchiger3 recently described two cases of anorectal syndrome with a positive Frei reaction, which exhibited chronic polyarthritis affecting the elbows, knees and wrists. The arthritic manifestations of one patient improved on resection of the rectum. In the other a para-articular abscess was discovered, which proved to be sterile by ordinary methods of bacteriologic examination. Whether these phenomena are produced by the virus or are merely expressions of sensitization to a foreign protein is yet uncertain. The fact that the virus of
REICHLE HS, CONNOR WH. LYMPHOGRANULOMA INGUINALEREPORT OF A CASE WITH INVOLVEMENT OF RETROPERITONEAL LYMPH NODES AND PROBABLE INVOLVEMENT OF THE HIP JOINT, ADRENALS AND KIDNEYS, WITH AUTOPSY. Arch Derm Syphilol. 1935;32(2):196–203. doi:10.1001/archderm.1935.01470020018002
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