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Article
August 1935

ARSENIC AS AN ETIOLOGIC AGENT IN CERTAIN TYPES OF EPITHELIOMA: DIFFERENTIAL DIAGNOSIS FROM, AND FURTHER STUDIES REGARDING, SUPERFICIAL EPITHELIOMATOSIS AND BOWEN'S DISEASE

Author Affiliations

ROCHESTER, MINN.

From the Section on Dermatology and Syphilology, The Mayo Clinic.

Arch Derm Syphilol. 1935;32(2):218-236. doi:10.1001/archderm.1935.01470020040005
Abstract

The purpose of this paper is to distinguish between superficial epitheliomas precipitated by, or resulting from, ingestion of, or exposure to, arsenic and superficial epitheliomatosis and Bowen's disease. The incidence and relative malignancy of these epitheliomas will be considered either in association with arsenical keratosis or independent of it. The literature has been reviewed, including about a thousand articles read in the last ten years on the subject of epithelioma and precancerous dermatosis, but reference is made only to recent or more pertinent articles.

MATERIAL FOR STUDY AND PROCEDURE

This study is based on a review of all the cases of arsenical keratosis and superficial epithelioma of the trunk and extremities seen in the section on dermatology of the Mayo Clinic from 1918 to 1934 and includes eighty-five cases of arsenical keratosis, in sixteen cases of which the arsenical type of epithelioma was present; two cases of

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