Inorganic salts are extremely important constituents of the skin and of all living protoplasm. The kind and amount of salt in a tissue may have a profound effect on its physiologic behavior. Chambers and Reznikoff1 have observed interesting effects of different salts on the cell membrane, protoplasmic consistency and activity of the ameba. Luithlen,2 in a study of the replacement of various cations in the skin by feeding diets having an acid ash (oats) and diets having a basic ash (green stuffs), observed that the inflammatory response of the skin was increased by the acid diet and diminished by the basic. From chemical analyses he concluded that an increase in the proportion of potassium in the skin parallels an increase in the irritability of the skin, while an increase in the amount of calcium is associated with diminished irritability of the skin. This concept has in general
KOOYMAN DJ. LXXIII.—STATE AND LOCALIZATION OF INORGANIC SALTS IN THE SKIN AS REVEALED BY EXTRACTION AND MICRO-INCINERATION. Arch Derm Syphilol. 1935;32(3):394–403. doi:10.1001/archderm.1935.01470030036005
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