The most striking symptom complained of by patients taking 1, 2, 4 alpha-di-nitrophenol for reduction of weight is copious sweating, especially at night. The thought that this drug in small doses might stimulate sufficient production of heat in patients suffering from ichthyosis to give them some relief during the winter months prompted us to try it out on an inmate of the New Jersey State Home for Boys.
A 16 year old white boy (P. J.) with ichthyosis served as the subject for our experiment. He was 62¼ inches (158.12 cm.) tall and weighed 108 pounds (49 Kg.). The boy gave a history of having had this condition since birth with spontaneous relief during the summer months (June to October). During the cold months he had an extensive dryness and fishlike scaling of the extensor surfaces of his arms, forearms and lower extremities below his knees. The remainder
Matthew Molitch. DI-NITROPHENOL IN TREATMENT OF ICHTHYOSIS. Arch Derm Syphilol. 1935;32(3):466–467. doi:10.1001/archderm.1935.01470030108012