The exact cause of hypertrichosis is unknown. Although it is generally considered to be due to some endocrine disturbance, the nature of this upset and the question whether the origin is monoglandular or polyglandular is in much dispute. Many endocrine syndromes are accompanied by abnormalities of growth of hair. In some, hypertrichosis of the face, trunk and limbs is accompanied by loss of hair or complete alopecia of the scalp. These disturbances may occur in patients with tumor or hyperfunction or hypofunction of the thyroid, pituitary, sex or adrenal glands. The fact that hypertrichosis so frequently appears first at puberty and at the menopause and during or following pregnancy indicates a relationship to the endocrine glands, especially the ovaries. On the other hand, many patients with pronounced generalized hypertrichosis show no detectable evidence of any endocrine disturbance, and many patients with various endocrine disorders have hair
NILES HD. RELATION OF THE ADRENAL GLANDS TO HYPERTRICHOSISRESULTS OF IRRADIATION OF THE ADRENALS AND REVIEW OF THE LITERATURE. Arch Derm Syphilol. 1935;32(4):580–588. doi:10.1001/archderm.1935.01470040037009
Customize your JAMA Network experience by selecting one or more topics from the list below.