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The discovery that the manifold intolerance reaction of an organism results from sensitization and depends on a specific reaction signifies an important advance in the field of medical science. In modern research in the field of allergy not only has the dependence of the allergic reaction on the antigen-antibody reaction been shown but it has been produced experimentally in animals and transmitted passively in human beings, achieving specific desensitization.
Precisely because of the far-reaching importance of allergy, the fact may easily be overlooked that not every intolerance reaction of an organism is based on a specific antigen-antibody reaction. This statement is illustrated in the case of the intolerance reaction which results from quantitative overdosage of stimuli and which yields the same clinical picture as the reaction based on specific sensitization. Thus, for example, all human beings will react with intolerance to abnormally large doses of arsphenamine, while only a
KEINING E, HOPF G. INJURIOUS EFFECTS OF SODIUM CHLORIDE AND THEIR PREVENTION. Arch Derm Syphilol. 1935;32(5):739–745. doi:10.1001/archderm.1935.01470050035005
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