The pioneer work of Kraus, Zondek1 and Petersen2 stimulated me to apply their methods to the investigation of diseases of the skin. It is the purpose of this paper to present the results of some of these studies, especially those dealing with the influence of the weather on cutaneous disease.
The first dermatosis studied was generalized scleroderma of the type beginning with symptoms of Raynaud's disease, which occurred in a woman 27 years of age. Chiefly because of the high calcium and low potassium content of the serum, the case was regarded as an example of sympathicotonia in which abnormal tone of the tissue is due to hyperfunction of the sympathetic nervous system. Studies of such vagotonic diseases as urticaria and eczema made it seem possible to catalog disease entities as sympathicotonic or vagotonic, depending on which component of the autonomic nervous system was functionally predominant.
SCHMIDT FR. SKIN DISEASES AND THE WEATHER. Arch Derm Syphilol. 1935;32(5):781–786. doi:10.1001/archderm.1935.01470050077012
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