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The occurrence of localized cutaneous reactions when procaine hydrochloride is used as a local anesthetic is so rare that I believe the following report to be of interest.
REPORT OF CASE
P. B., an unmarried woman, aged 30, received an intracutaneous injection of 1 cc. of 2 per cent procaine hydrochloride without epinephrine in the flexor region of the left wrist before electrodesiccation of a verruca. A dressing of plain petrolatum and gauze was applied. About twelve hours later the patient complained of severe burning and pruritus at the site of the injection. An oval, well defined elevated vesicular area about 3 cm. in diameter appeared. Three thin, linear vesicular stripes extended up the flexor aspect of the forearm from the site of the reaction. Vesicles from the size of a pinpoint to that of a pinhead composed the linear lesions. The right epitrochlear gland was slightly enlarged. No
Robinson SS. AN UNUSUAL CUTANEOUS REACTION TO PROCAINE HYDROCHLORIDE. Arch Derm Syphilol. 1935;32(6):922. doi:10.1001/archderm.1935.01470060087006
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