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Article
March 1936

LXXII. PITYROSPORUM OVALE (BOTTLE BACILLUS OF UNNA, SPORE OF MALASSEZ): CULTIVATION AND POSSIBLE RÔLE IN SEBORRHEIC DERMATITIS

Author Affiliations

ST. LOUIS

This work was done under a grant from the Lambert Pharmacal Co.

Studies, observations and reports from the Dermatological and Research Departments of the Barnard Free Skin and Cancer Hospital, and service of Drs. M. F. Engman and W. H. Mook, St. Louis, Mo.

Arch Derm Syphilol. 1936;33(3):457-472. doi:10.1001/archderm.1936.01470090047004
Abstract

Since Malassez1 described for the first time the microbe now known as Pityrosporum ovale, the importance of that fungus in seborrheic dermatitis has been emphasized and disputed. The artificial cultivation of the fungus in sufficient quantity for experimental purposes had been attempted unsuccessfully many times. This was finally accomplished by one of us (Moore), as reported elsewhere.2 This paper, therefore, is concerned with experimental studies with P. ovale on man and on laboratory animals to determine the possible rôle of the fungus in seborrheic dermatitis.

A number of workers claiming to have grown the organism have attempted experiments to confirm or disprove the general opinion as to the significance of P. ovale in the disease. It is our opinion that the microbes obtained were too different morphologically and physiologically to be classed as P. ovale. The reactions obtained by inoculating persons with these microbes have been in

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