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Article
July 1936

ARTERIAL EMBOLISM FOLLOWING INTRAMUSCULAR INJECTION OF A BISMUTH PREPARATION

Author Affiliations

NEW YORK

From the department of syphilology, service of Dr. Joseph Lebenstein, the Hospital for Joint Diseases.

Arch Derm Syphilol. 1936;34(1):93-96. doi:10.1001/archderm.1936.01470130096008
Abstract

Bismuth preparations have been used extensively by intramuscular injection for spirocheticidal purposes since 1922. The first instances of arterial embolism were reported before the Schlesische Dermatologische Gesellschaft by Freudenthal1 in 1923. The literature now contains accounts of some fifty cases, reported mainly from France and Germany. In the United States, Gammel2 has noted five, and De Wolf3 two, such accidents. Similar pictures have been observed following the intramuscular injection of mercury, but the pathogenesis had not been understood.1

REPORT OF A CASE

P. C., a white man aged 38, had begun antisyphilitic treatment seven years previously because of increasing deafness, perforation of the nasal septum and a positive Wassermann reaction of the blood. Since then he had received numerous but irregular courses of treatment with neoarsphenamine and bismuth, the Wassermann reaction of his blood becoming frequently but not consistently negative.

The fifth injection of

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