Considerable investigation has been conducted regarding the rôle that sulfhydryl compounds play in the cellular activity of normal and abnormal growth, as a factor in oxidation and reduction and as detoxifying agents. The study herein reported embraces these phases of sulfur metabolism in relation to the physiology of the skin in the normal state, in systemic pathologic states and in diseases of the skin. In previous communications1 we reported the results of studies and reviewed data showing the important rôle that cystine plays in the formation and development of keratin-containing tissue, especially hair, wool and nails. Sulfur in the skin exists essentially in organic combination. It is believed that a large portion is in the form of cystine and cysteine. Other known sulfhydryl compounds in the skin are glutathione and methionine.
The total sulfur content of the skin was determined rather than the amount of the individual,
KLAUDER JV, BROWN H. CERTAIN PHASES OF SULFUR METABOLISM OF THE SKIN. Arch Derm Syphilol. 1936;34(4):568–581. doi:10.1001/archderm.1936.01470160015003
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