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December 1936


Arch Derm Syphilol. 1936;34(6):997-1007. doi:10.1001/archderm.1936.01470180064007

The term hemangio-endothelioma is loosely used to identify tumors exhibiting similar clinical character but quite different microscopic structures. It is our purpose in this article to give a clear definition of hemangio-endothelioma and to attempt to show what tumors may rightfully be included under that title.

A hemangio-endothelioma is an angiomatous tumor possessing low grade malignancy, presenting a characteristic clinical appearance and having a precise histologic structure. It is composed essentially of blood spaces and vessels in different stages of development. The blood does not circulate through the tumor mass because of the immaturity of many of the vessels. A true endothelioma of the skin does not exist, for the origin of an endothelioma must be from endothelially lined structures, such as blood or lymph vessels; therefore, the so-called endothelioma of the external surface is either a hemangio-endothelioma or a lymphangio-endothelioma. In many cases a tumor called endothelioma is