The belief that there exists a relationship between acne vulgaris and an altered function of the endocrine glands has been expressed so often and for so long that it hardly seems necessary to repeat details here. However, a few salient factors in this regard should be mentioned. Although the relationship is not definitely proved, most modern writers do not hesitate to state without reservations that acne vulgaris is due to a dysfunction of the endocrine glands.
McCARTHY L, HUNTER OB. FAILURE OF THERAPY WITH GLANDULAR PREPARATIONS IN ACNE VULGARIS. Arch Derm Syphilol. 1937;35(2):211–225. doi:10.1001/archderm.1937.01470200011002
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