The rapid disappearance of the spirochetes (Spirochaeta pallida) from the chancre and the relatively prompt healing of the cutaneous and mucosal manifestations of early syphilis following the administration of arsphenamine are some of the spectacular achievements of chemotherapy. Furthermore, the observations of the Cooperative Clinical Group 1 show that the adequate treatment of acute syphilis by the continuous and judicious use of modern antisyphilitic remedies produces a clinical and serologic cure in a large proportion of cases. With this advancement in the treatment of syphilis differences of opinion have arisen regarding the influence of modern antisyphilitic drugs on the course of the disease, and the medical literature is replete with articles in which the various phases of this complex problem are discussed. Some observers have argued that since the introduction of arsphenamine there has been an increase in the incidence of late visceral manifestations of syphilis and
NETHERTON EW. ARSPHENAMINE-RESISTANT SYPHILIS. Arch Derm Syphilol. 1937;35(4):607–632. doi:10.1001/archderm.1937.01470220047005
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