This study was undertaken to test the possibility that defective hepatic function may be a factor in the production of certain dermatoses. As is well known, the liver is interposed between the gastro-intestinal tract and the general circulation, and one of its functions is to prevent toxic substances from the gastro-intestinal tract from entering the blood stream. This is accomplished, to a large extent, by detoxification, the processes of which include oxidation, reduction and conjugation. Theoretically, therefore, failure of this function of the liver might permit entry of toxic substances into the general circulation and thus lead to their deposition in the skin. That defective hepatic function may be a factor is suggested by the frequent occurrence of cutaneous lesions in cases of diabetes, a disease in which disturbances of hepatic function have been found to be common.1
A difficulty of putting the aforementioned possibility to the test of
BURGESS JF, RABINOWITCH IM. BILE PIGMENT METABOLISM IN DISEASES OF THE SKIN. Arch Derm Syphilol. 1937;35(5):932–941. doi:10.1001/archderm.1937.01470230170010
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