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May 1937

By-Effects in Salvarsan Therapy and Their Prevention, with Special Reference to the Liver Function

Arch Derm Syphilol. 1937;35(5):1005. doi:10.1001/archderm.1937.01470230243019

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The author has correlated the complications of treatment of syphilis as observed in the patients of the Rigshospital, Copenhagen, Denmark. The material is presented in three parts: The first section consists of data on arsphenamine erythema, jaundice, albuminuria and involvement of the joints. The second section deals with the by-effects of arsphenamine and the value of a dextrose solution as a solvent in the prevention of such complications. The value of "functional liver tests" in the appraisal of these complications is likewise discussed. The third section is based on the "functional liver tests" made on a group of hospitalized patients. The last eighty pages of the book consist of 125 case reports.

The observations and deductions presented by the author are in accord with the experiences reported by numerous syphilologists in the American medical literature in the past. In this country the test of hepatic function has not

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