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June 1937


Author Affiliations


From the Department of Dermatology and Syphilis of the Massachusetts General Hospital, Dr. Lawrence Oliver, Chief.

Arch Derm Syphilol. 1937;35(6):1120-1129. doi:10.1001/archderm.1937.01470240112011

In a disease of which the etiology is not known and for which a specific therapy has not been found any type of treatment that offers possibilities may be justly grasped with a ray of hope. Such a malady is psoriasis, from the sufferers of which venders of nationally advertised nostrums have yearly garnered untold sums. With these facts in mind the following study was undertaken.

In reviewing the literature on manganese as a therapeutic agent one finds numerous reports from the European clinics on its use in the treatment of psoriasis. We were able to obtain an unlimited supply of a colloidal preparation of the substance, and the following investigation evolved.


Before attempting to develop the rationale of a treatment for any disease it is fitting to ascertain what is known of its etiology. To that end we have reviewed the voluminous literature of the past