In the course of our work we observed a patient with a condition clinically diagnosed as syphilis the globulin content of whose serum was 4.4 per cent. Previous research>1 has shown that hyperglobulinemia is not characteristic of the syphilitic syndrome. The history was carefully checked, and it was discovered that the patient had responded positively to the Frei test. This stimulated further investigation of the biochemistry of the blood of patients with lymphogranuloma venereum. To date twenty-seven patients affected with the disease for periods varying from three weeks to seventeen years have been examined. All responded positively to the Frei test and showed clinical manifestations of inguinal adenopathy, rectal stricture and esthiomene of lesser or greater severity. The lipid partition in addition to the albumin-globulin ratio was studied. With few exceptions, all the serums were analyzed for total lipids, total cholesterol, cholesterol esters, free cholesterol, alcohol-ether-soluble phosphorus (otherwise referred
ROSEN I, ROSENFELD H, KRASNOW F. LYMPHOGRANULOMA VENEREUM: PROLONGED DERANGEMENT OF THE SERUM LIPIDS AND PROTEINS: PRELIMINARY REPORT. Arch Derm Syphilol. 1937;36(2):318–320. doi:10.1001/archderm.1937.01480020074010
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