In recent years an interesting insight into the relationship of immediate to delayed reactions has been given by Tezner,1 Simon and Rackemann,2 Rudolph and Cohen3 and others. By experiments on immunization with albumin, pollen and ascaris antigen Tezner has demonstrated that in the course of the immunization the two forms of reaction occur in a definite cycle in a normal person. The delayed reaction appears first and is followed a week later by an immediate reaction. During the further course of the immunization the delayed reaction disappears and then the immediate reaction. On the other hand, in immunization (desensitization) of an allergically hypersensitive (atopic) person there is no delayed reaction, and only a slight diminution of the primary immediate reaction is observed. However, a delayed reaction can occasionally be produced by immunization of a person whose hypersensitivity is less marked. Consequently, Tezner concluded that there is a
MARCUSSEN PV. RELATIONSHIP OF THE URTICARIAL TO THE INFLAMMATORY REACTION TO TRICHOPHYTIN. Arch Derm Syphilol. 1937;36(3):494–514. doi:10.1001/archderm.1937.01480030021003
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