In the course of an investigation of the responses elicited in the skin by intracutaneous injections of various trichophyton extracts in a series of over four hundred patients, we encountered an unusual phenomenon in six instances.
Our method of testing the skin of these patients included the injection of 0.1 cc. of each of three different stock trichophytins: (1) a 1: 100 dilution of Metz trichophytin prepared from Trichophyton gypseum, Trichophyton cerebriforme, Trichophyton migroides, Trichophyton rosaceum, Trichophyton violaceum and Trichophyton crateriforme—six strains—(2) a 1: 30 dilution of Lederle trichophytin prepared from one strain of Trichophyton interdigitale, and (3) undiluted Bischoff dermatomycol, a clasovaccine of Jausion and Sohier prepared from more than three hundred strains of fungi.
When the six patients' skin at the sites of the tests was examined after forty-eight hours, no reactions were visible; but flare-ups were in evidence at one or more of the sites of injection
LEWIS GM, SULZBERGER MB, WISE F, Hopper ME. TRICHOPHYTIN AND ALLERGY TO TRICHOPHYTIN: II. OBSERVATIONS ON THE VARIABILITY OF CUTANEOUS RESPONSES TO TRICHOPHYTIN. Arch Derm Syphilol. 1937;36(3):548–551. doi:https://doi.org/10.1001/archderm.1937.01480030075008
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