Three undoubted cases of benign hepatitis of early syphilis and 1 probable one are presented from the United States Public Health Service Venereal Disease Clinic, Hot Springs, Ark., because such cases are rare. Three of the patients had secondary syphilitic lesions of the skin or mucous membranes, and 1 had a primary lesion. Two of them showed a Herxheimer reaction when treatment was begun with neoarsphenamine. The jaundice in all 4 cases disappeared promptly under treatment for syphilis.
Only the 4 previously mentioned cases of benign hepatitis of early syphilis have been recorded at the clinic during the five years from 1931 to 1935, making an incidence of 4 cases among 4,820 cases of recent syphilis (syphilis of one year's duration or less), or 1 case among 1,200, as follows:Three of the patients were admitted to the clinic within a period of five weeks.Moore1 stated
WAUGH JR. BENIGN HEPATITIS OF EARLY SYPHILIS. Arch Derm Syphilol. 1937;36(3):599–605. doi:10.1001/archderm.1937.01480030126012
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