Andrews1 stated that age and sex are both predisposing factors in the cause of cutaneous diseases and that there are certain conditions of the skin that are found almost exclusively in definite regions of the body. Schmidt2 concluded that the type of biologic and cutaneous reaction is conditioned by the individual constitution and the degree of instability of the autonomic nervous system, and that the weather is an important environmental factor in precipitating cutaneous symptoms. Schmidt3 had previously shown by means of staining reactions and by intracutaneous injections of methylene blue that the requirement for oxygen varies in different parts of the surface of the body. Kadisch4 had shown a relation between the localization of infections, the temperature and the supply of oxygen to the skin.
Oxidation, either aerobic (by means of oxygen directly) or anaerobic (by means of easily reducible substances) is essential for the
ADAMS PD. EFFECT OF AGE ON CONSUMPTION OF OXYGEN AND COMPOSITION OF THE SKIN OF THE ALBINO RAT. Arch Derm Syphilol. 1937;36(3):606–610. doi:https://doi.org/10.1001/archderm.1937.01480030133013
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