Since the introduction of arsphenamine therapy the syphilologist has been confronted constantly with the problem of involvement of the liver. Despite the existing controversy as to the pathogenesis of hepatic complications occurring during treatment, arsenic is without doubt the offending agent in the vast majority of instances. If it were possible to devise a method whereby the earliest phases of syphilitic hepatitis and particularly those of arsphenamine hepatitis could be readily recognized, a distinct advance in the management of syphilis would be accomplished. In this paper an effort is made to create a plan for detecting early hepatic abnormalities caused by arsenic.
The liver, because of its enormous blood supply, is invaded by countless numbers of organisms during their early dissemination through the vascular system; yet extensive acute parenchymatous hepatitis is rare in early stages of syphilis. Reports in the literature are meager as to pathologic changes in
IRGANG S. THE PROBLEM OF INVOLVEMENT OF THE LIVER IN SYPHILIS: COMMENT ON ITS MORE IMPORTANT PHASES, WITH CASE REPORTS. Arch Derm Syphilol. 1937;36(4):685–707. doi:10.1001/archderm.1937.01480040002001
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