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The author has observed "dozens of cases" of an illness which he classifies as pemphigus foliaceus (Cazenave) with certain variations which he attributes to its occurrence in a tropical area. The condition is seen most frequently in patients between the ages of 16 and 30, with limits of 7 and 51 years. It is equally common in the two sexes. It begins usually as a bullous eruption, soon becoming generalized and leading to the picture of erythroderma. Common associated symptoms are partial or complete alopecia, hyperkeratosis of the palms and soles, onychoschizia and onychorrhexis, muscular atrophy, ankylosis of the large joints and occasionally a papillomatous condition of the scalp. There are never any lesions of the mucous membranes. Hyperpigmentation, when it occurs, is a favorable prognostic omen. The urine contains traces of albumin. The sedimentation rate of the erythrocytes is often markedly accelerated; the cholesterol content of the blood usually
Contribuição ao estudo do pemphigo no Estado de São Paulo. Arch Derm Syphilol. 1937;36(4):935. doi:10.1001/archderm.1937.01480040252026
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