Lymphotropism of the virus of Nicolas-Favre's disease is an undisputed fact; neurotropism and dermotropism have only recently been considered as possible. Local cutaneous lesions distinctly lymphogranulomatous in nature have been described by Nicolas and Favre, Massia and Lebeuf, Chevallier and Bernard, Pinard and Fiehrer, and Sézary. Howard and Strauss1 found anal condylomas in a man and regarded them as an unusual manifestation of the disease.
Two types of general cutaneous lesion have been described in lymphogranuloma venereum (inguinale), one resembling erythema multiforme and the other erythema nodosum.
Koppel2 reported three cases of the inguinal syndrome accompanied by erythema nodosum; Hellerstroem3 described similar cutaneous lesions in four such cases; Buschke referred to one case in which the condition was accompanied by an exanthem; Kleeberg4 and Kerl reported metastatic cutaneous symptoms resembling erythema nodosum in addition to inguinal adenopathy in lymphogranuloma venereum; Nicolau5 described the case of
COUTTS WE, AHUMADA H. PENOSCROTAL ELEPHANTIASIS OF LYMPHOGRANULOMATOUS ORIGINDESCRIPTION OF A CASE WITH PSORIASIFORM CUTANEOUS LESIONS AND OTHERS RESEMBLING AN ECTHYMATOUS PYODERMA. Arch Derm Syphilol. 1937;36(5):1014–1017. doi:10.1001/archderm.1937.01480050080010
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