During the past few years the etiology of scleroderma has received considerable attention from European and American investigators. Among many of the possible causes, the glands of internal secretion1 and the sympathetic nervous system2 have been considered both separately and together as playing important rôles in the production of the pathologic changes noted in this disease. Osler1i and Oliver,3 however, have summed up the actual knowledge as to the source of scleroderma in the statement that little progress has been made in determining its exact cause. Sclerodactylia has been classified as an angiotrophoneurosis related to endocrine disturbance and to dysfunction of the sympathetic nervous system.4 Sellei5 has recently suggested dysfunctions of ferment-producing organs, principally the pancreas, as etiologic agents in scleroderma and sclerodactylia and has advocated the administration of pancreatic, duodenal and gastric ferments for the relief of the vascular spasm, especially when associated
ROBINSON SS. SCLERODERMA AND SCLERODACTYLIA ASSOCIATED WITH INTERMITTENT CLAUDICATION. Arch Derm Syphilol. 1937;36(5):1054–1057. doi:10.1001/archderm.1937.01480050120017
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