The application of cold produces effects varying naturally with the skin's resistance, the temperature of the agent used at the time of contact, the amount of pressure applied and its duration. These effects are useful in a variety of dermatologic conditions.
The local action of solid carbon dioxide has been well known for many years. Since 1906, when I was working in Dr. George Henry Fox's clinic (the Vanderbilt clinic) under Jackson and saw various uses to which solid carbon dioxide was put, I have been using this agent. At that time, to increase the cold, ether was added. Liquid air, being twice as cold, proved somewhat more useful than solid carbon dioxide, but it has always been difficult to obtain and to keep.
For the past few months I have been using a new agent in this field, a freezing gas consisting of butane, isobutane and propane. When sprayed
HARRY E. ALDERSON. COLD THERAPY IN DERMATOLOGYA NEW FREEZING GAS. Arch Derm Syphilol. 1938;37(2):234–237. doi:10.1001/archderm.1938.01480080067007