Artificial fever, induced either by the inoculation of malarial parasites or by various physical agents, has become an integral part of the management of neurosyphilis. Malarial therapy was introduced by Wagner-Jauregg1 for the treatment of dementia paralytica in 1918. Many later reports2 indicated that the production of fever was of distinct value in treating not only dementia paralytica but other types of neurosyphilis. Subsequently other methods of inducing artificial fever were introduced, including inoculation with the parasites of rat bite fever and of relapsing fever; injection of vaccines, such as bacterial vaccine made from the typhoid bacillus and the paratyphoid A and B bacilli; injection of sulfur in oil and methods that used physical means alone, such as diathermy, radiothermy, the use of inductotherm, electric blankets, hot baths and heat cabinets such as the Kettering hypertherm and a simplified procedure called the "blanket method." The "blanket method"3 was
EPSTEIN NN. ARTIFICIAL FEVER AS AN ADJUNCT IN THE TREATMENT OF NEUROSYPHILIS. Arch Derm Syphilol. 1938;37(2):254–266. doi:10.1001/archderm.1938.01480080087010
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