In a previous report by us1 there was developed a new conception of the bacteriologic characteristics and the pathogenesis of noncaseating epithelioid tuberculosis, which was based on new biologic experiments with the tubercle bacillus. Briefly, the import of these studies was that during the life of the tubercle bacillus it assumes several nonacid-fast or partially acid-fast forms, which at present are included in wholly different taxonomic categories of bacteria, such as streptotrichotic forms, diphtheroids and certain cocci.
The proof of this contention lies in the fact that we have observed the dissociation of tubercle bacilli into such organisms and, on occasion, their reversion into the original tubercle bacilli. Moreover, these cultural phases are more or less interchangeable. On the other hand, their stability is relatively great, and the changes are effected only with difficulty.
It is the latter circumstance that explains in part the bacteriologic anomalies of noncaseating epithelioid
BEINHAUER LG, MELLON RR. PATHOGENESIS OF NONCASEATING EPITHELIOID TUBERCULOSIS OF HYPODERM AND LYMPH GLANDS. Arch Derm Syphilol. 1938;37(3):451–460. doi:10.1001/archderm.1938.01480090080008
Dermatology in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.