[Skip to Navigation]
April 1938


Arch Derm Syphilol. 1938;37(4):736. doi:10.1001/archderm.1938.01480100189018

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This comprehensive monograph is based on the author's personal observations of 200 patients and a critical review of more than 1,000 cases in the literature. It opens with a discussion of the general symptoms of arsenical intoxication. The author objects to the term "arsenical intoxication" in cases in which the symptoms disappear spontaneously. He cites the frequent occurrence of diarrhea, conjunctivitis and herpes zoster and their spontaneous disappearance during the continued administration of arsenic.

He discusses arsenical tolerance and states that it is greater in children than in adults. The effect of the drug on each organ and the arsenical content of the bodily secretions are discussed. The involvement of the nervous system occurs through (1) the arsenical effects as such (permeability); (2) the influence on the capillaries, such as hyperemia or anemia following hyperemia of the splanchnic viscera; (3) autointoxication following arsenical involvement of one of the viscera. He

First Page Preview View Large
First page PDF preview
First page PDF preview
Add or change institution