The presence of bismuth in the cerebrospinal fluid after medication with iodobismitol has been questioned by some in the face of positive evidence, first reported from this institution,1 and of independent confirmation by others.2 Some who have questioned this evidence have submitted positive evidence of their own for penetration of the central nervous system or of the cerebrospinal fluid,3 but, unfortunately, owing to equivocation or compromise, lack of clarity, incompleteness of data, uncertainty of methods and exaggeration or misconception of the concept of permeability, these reports have left much to be desired as regards the validity of the original claims.
For instance, in New and Nonofficial Remedies4 it is stated:
It is claimed for sodium iodobismuthite (the bismuth compound in Iodobismitol with saligenin N.N.R.) that it has the quality of appearing in the spinal fluid and of penetrating the brain tissue. This claim and therapeutic indications
HANZLIK PJ. BISMUTH IN CEREBROSPINAL FLUID AFTER ADMINISTRATION OF IODOBISMITOL. Arch Derm Syphilol. 1938;37(6):1003–1007. doi:10.1001/archderm.1938.01480120069011
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