The number of cases of urticaria observed at the dermatologic clinic at Northwestern University has increased approximately 20 per cent from 1928 to 1935. Careful study, including cutaneous tests, often revealed no definite etiologic factors. Various dietary restrictions during treatment sometimes resulted in an exacerbation of symptoms. This observation and the fact that a number of the patients had been on relief while others had been on a diet containing limited amounts of citrus fruits and fresh vegetables for a prolonged period led me to think of the possibility of a dietary deficiency as an etiologic factor in urticaria.
In 1921 Hess1 suggested that there is a failure of the integrity of the epithelium of the blood vessels in vitamin C deficiency and that this is probably due to a lesion of the endothelial cells or of their cementing substance.
Further study of the pathologic aspects of vitamin C
ROSENBERG WA. VITAMIN C DEFICIENCY AS A CAUSE OF URTICARIA. Arch Derm Syphilol. 1938;37(6):1010–1014. doi:10.1001/archderm.1938.01480120076013
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