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Attempts to use galvanic current for the introduction of medicaments through and into the skin can be traced to the middle of the eighteenth century. In the last two decades there has been a considerable revival of interest in electrophoresis. This has prompted the author to undertake a critical study of the knowledge accumulated and to carry out extensive experiments and clinical work with this method.
This excellent monograph consists of four parts, of which the first deals with the physical chemistry and the physiology of electro-endosmosis, a term the author chooses because the mechanism of the introduction of chemicals into the living cell differs from iontophoresis and has to be interpreted as electrokinesis through complicated membranes. This consideration is of great practical importance. The rest of the chapter deals with the physiologic aspects and the technic of electrophoresis and contains particularly interesting data about electro-endosmotic local anesthesia. That substances
Elektroendosmose am Menschen experimentell und klinisch. Arch Derm Syphilol. 1938;37(6):1093. doi:10.1001/archderm.1938.01480120159025