The experimental production, through internal channels, of an immunologic wheal on normal and on abnormal skin has been reported in previous communications.1 It may be outlined briefly as follows: From 0.01 to 0.05 cc. of human serum obtained from a food-sensitive patient is injected intracutaneously into a subject. After twenty-four or forty-eight hours he is fed a definite amount of the specific offending food to which he has been locally sensitized. A reaction, consisting of a wheal with surrounding erythema and accompanied with pruritus, appears at the passively sensitized site from two to ninety minutes after the ingestion of the excitant. The steps in the development of this wheal and the various forms it may assume have been described in detail in the previously cited publications. This technic for the production of wheals is virtually the same as that which was devised by Matthew Walzer2 to demonstrate the
WALZER A. URTICARIA: VI. A NEW IMMUNOLOGIC WHEAL PRODUCED EXPERIMENTALLY BY REVERSE TECHNIC. Arch Derm Syphilol. 1938;38(1):1–11. doi:10.1001/archderm.1938.01480130004001
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