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July 1938

ERYTHROMELALGIA: Report of a Case of Its Association with Chronic Gout with Relief of Symptoms for Two Years After Intravenous Administration of Typhoid Vaccine

Author Affiliations

Manchester, Pa.

Arch Derm Syphilol. 1938;38(1):73-74. doi:10.1001/archderm.1938.01480130076011

Erythromelalgia was first described by Graves1 in 1864 and by Mitchell2 in 1872 and is characterized by shooting, throbbing or burning pains associated with duskiness, congestion or redness of the affected part. The five essential features necessary for establishing a diagnosis are: (1) burning pain in the hands or the feet, (2) aggravation of symptoms by heat or exercise, (3) relief by elevation, rest or cold, (4) increased local heat and (5) refractoriness to treatment.


History.—  On Nov. 5, 1936, I was called to see J. F., a white man aged 50, a laborer. He had both feet suspended in a basin of cold water in order to obtain relief from local burning and throbbing pain. They were swollen and hot to the touch but did not pit on pressure. The symptoms were aggravated by local pressure, suspension in warm water or application of an

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