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Article
August 1938

ARSENICAL DERMATITIS PRODUCED IN TREATMENT OF TRICHOMONAS VAGINITIS: REPORT OF FIVE CASES

Author Affiliations

NEW YORK

From the Department of Dermatology, College of Physicians and Surgeons, and the Vanderbilt Clinic, Columbia University.

Arch Derm Syphilol. 1938;38(2):198-199. doi:10.1001/archderm.1938.01480140038003

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Abstract

Acetarsone and related compounds containing pentavalent arsenic are used with increasing frequency in the treatment of infections caused by Trichomonas vaginalis. It seemed of interest to report briefly four cases in which localized dermatitis followed the use of one of these compounds and in which the course, the appearance and the distribution of the eruption were strikingly similar. In a fifth case to be reported the dermatitis produced was generalized and indistinguishable from that produced by the arsphenamines.

REPORT OF CASES 

Cases 1, 2 and 3.—  Three women with resistant trichomonas vaginitis received weekly or bimonthly treatments over periods of eight, ten and fourteen months, respectively. None gave a history of previous dermatitis or of treatment with arsenic. All received the insufflation treatment for infection due to Trichomonas with a preparation labeled "powdex—formula 21." The composition stated on the label wasNo cutaneous symptoms were noted by any of these

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