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Article
October 1938

LIQUEFYING NODULAR PANNICULITIS: REPORT OF A CASE

Author Affiliations

PHILADELPHIA

From the Department of Dermatology and Syphilology of the School of Medicine, University of Pennsylvania, John H. Stokes, M.D., Director.

Arch Derm Syphilol. 1938;38(4):535-544. doi:10.1001/archderm.1938.01480160027003
Abstract

Circumscribed or nodular inflammatory diseases of the subcutaneous fatty tissue have not been the subject of a great deal of study, as this tissue is seldom the primary site of a disease process. Most frequently the involvement is secondary to an incidental or adjacent pathologic focus. However, a number of distinct clinical entities in which the subcutaneous fatty tissue apparently plays the fundamental or characteristic role have recently been receiving a greater degree of recognition.

Most of these entities can be grouped under the generic term subcutaneous fat necrosis,1 although many other terms indicative of the same process are found in the literature, such as cystosteatonecrosis,2 lipogranuloma,3 lipogranulomatosis,4 lipodystrophy5 and liponecrosis.6 The process is essentially granuloma of the fatty tissue in which the fat undergoes lysis and subsequent phagocytosis and in which characteristic foam cells and giant cells of foreign body type are present.

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