Germanin was introduced in 1928 by Kleine1 for the treatment of trypanosomiasis, in which it has been somewhat effective. Veiel2 in 1931 first suggested the use of germanin in the treatment of pemphigus, reporting 3 cures among 4 cases. Fabian3 in 1933 reported the clinical cure of pemphigus in a boy 4 years old after four injections of germanin, after other measures had been ineffective. An elderly woman with diabetes and pemphigus was treated with this drug by Fabián; a high fever developed, and the patient died after the third injection. In the same year Zoon4 reported the use of germanin in a case of pemphigus; there was rapid healing of lesions, followed by a recurrence in six months which proved fatal in spite of further medication. Zoon gave germanin also to 6 patients afflicted with dermatitis herpetiformis. There were a favorable response in 5 cases