A preliminary report of the use of snake venom in the treatament of herpes simplex follows:
In March 1935, Peck1 presented before the Section on Dermatology and Syphilis of the New York Academy of Medicine 3 cases of pemphigus treated with moccasin venom. He expressed the belief that he was dealing with a dermotropic virus and that the moccasin venom produced a barrier in the capillaries of the skin which the virus in the circulation could not break through to cause the clinical manifestations.
This report suggested that it might be worth while to investigate the possible influence of moccasin venom on herpes simplex. Moccasin venom with a dilution of 1:3,000 was given intradermally in 0.2 cc. The local reaction was mild, and no constitutional symptoms The patient was advised to make no local applications to the lesions at any time during treatment.
Fifteen patients with herpes simplex have
KELLY RJ. TREATMENT OF HERPES SIMPLEX WITH MOCCASIN VENOM. Arch Derm Syphilol. 1938;38(4):599–602. doi:10.1001/archderm.1938.01480160091010
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