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October 1938


Arch Derm Syphilol. 1938;38(4):619-620. doi:10.1001/archderm.1938.01480160111013

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Recently, I investigated the potential properties of a soap solution as a cutaneous irritant. The usual patch tests with the constituent materials of the solution were made on normal skins, and it was found, to my surprise, that the results were consistently negative. The gauze patches were then subjected to qualitative and Quantitative chemical studies, and it was learned that the one suspected ingredient was dissipated after a few hours, thus rendering valueless the ordinary twenty-four and forty-eight hour patch tests. It was necessary to devise some means of performing "continuous" patch tests, so that the test solution could be renewed at intervals to assure continuous contact with the skin. Various kinds of adhesive patches and ordinary shields used in vaccination were found to be impractical for study of a large group of cases; the celluloid disk shown in the sketch was tried and proved in every way suitable.


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