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Article
November 1938

SIGNIFICANCE OF PORPHYRIN CONTENT OF URINE IN DERMATOSES ASSOCIATED WITH SENSITIVITY TO LIGHT

Author Affiliations

ROCHESTER, N. Y.

From the Department of Medicine, School of Medicine and Dentistry, and Strong Memorial Hospital, the University of Rochester.

Arch Derm Syphilol. 1938;38(5):727-736. doi:10.1001/archderm.1938.01480170051005
Abstract

In the group of dermatoses in which photosensitivity is present it has been, generally speaking, impossible to find a cause for the sensitivity. In the rare condition hydroa aestivale with congenital porphyria, however, it seems probable that the cutaneous manifestations are due to sensitization produced by the porphyrins, though other factors, doubtless, are involved. It is known that sensitivity to light can be experimentally produced in the lower organisms, in animals and in man by the injection of porphyrins prior to exposure to sunlight. It therefore occurred to us that a study of the excretion of porphyrin in a variety of dermatoses in which there seemed to be light sensitivity clinically might be of interest. With this in view, we determined the level of excretion of the ether-soluble porphyrins in the urine of persons with a variety of dermatoses, most of which had a photosensitive aspect. Before we consider the

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