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Article
December 1938

EVALUATION OF THE FREI TEST WITH MOUSE BRAIN ANTIGEN: COMPARISON WITH HUMAN ANTIGEN

Author Affiliations

NEW YORK

From the Department of Dermatology and Syphilology, New York University College of Medicine, and the Dermatologic Service of the Bellevue Hospital, service of Drs. Howard Fox and Edward R. Maloney.

Arch Derm Syphilol. 1938;38(6):930-938. doi:10.1001/archderm.1938.01480180096011
Abstract

Today the number of cases of lymphogranuloma venereum recognized has greatly increased, no doubt through better diagnosis. This has been observed by workers in different countries. At the Bellevue Hospital more than 100 cases have been followed in the past three years.

Typical lymphogranuloma of the inguinal type is fairly easy to recognize clinically. However, in cases of atypical buboes and rectal strictures great help has been given by the Frei test.

The present study was prompted by the difficulty in determining whether the result of a Frei test was positive or negative in a fairly large percentage of cases.

Frei1 first published his observations on the use of an antigen derived from the pus of an unruptured bubo in a case of lymphogranuloma venereum. He proved that the intradermal injection of this antigen was useful as a diagnostic aid. The value of the test has been corroborated by

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