Today the number of cases of lymphogranuloma venereum recognized has greatly increased, no doubt through better diagnosis. This has been observed by workers in different countries. At the Bellevue Hospital more than 100 cases have been followed in the past three years.
Typical lymphogranuloma of the inguinal type is fairly easy to recognize clinically. However, in cases of atypical buboes and rectal strictures great help has been given by the Frei test.
The present study was prompted by the difficulty in determining whether the result of a Frei test was positive or negative in a fairly large percentage of cases.
Frei1 first published his observations on the use of an antigen derived from the pus of an unruptured bubo in a case of lymphogranuloma venereum. He proved that the intradermal injection of this antigen was useful as a diagnostic aid. The value of the test has been corroborated by
REIDER RF, CAÑIZARES O. EVALUATION OF THE FREI TEST WITH MOUSE BRAIN ANTIGEN: COMPARISON WITH HUMAN ANTIGEN. Arch Derm Syphilol. 1938;38(6):930–938. doi:10.1001/archderm.1938.01480180096011
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