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December 1938


Arch Derm Syphilol. 1938;38(6):1006-1013. doi:10.1001/archderm.1938.01480180172022

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Ulcers of the Leg, Associated with Sickle Cell Anemia, in Sisters. Presented by Dr. W. F. Schwartz (from the Department of Dermatology and Syphilology, City Hospital). 

Case 1.—  L. C., a girl aged 13, presents an indolent ulcer 1.5 by 2 cm., which developed on the anterior surface of the left leg ten months ago, after minor trauma. The ulcer attained its present size within a few weeks. There have been no other lesions.The spleen and liver are not palpable.This patient showed 20 per cent sickling of red cells after twenty-four hours on April 11, 1938, but at the present time there is less than 5 per cent sickling. There were 4,650,000 erythrocytes, 80 per cent hemoglobin and 0.9 and 1.1 per cent reticulocytes, respectively. The Kline reaction was negative.The urine showed no bromine. The tuberculin tests gave negative results with dilutions down to 1:100,000. A

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