Jaundice as a complication of syphilis has long been known. The relationship was apparently pointed out first by Paracelsus, early in the sixteenth century. An occasional reference appears in the literature between this time and 1853, when Gubler published a report of 7 cases of what he called true syphilitic jaundice. Ricord had described jaundice in 2 cases of early syphilis but had recorded them merely as observations. A little later Lanceraux reported 20 more cases. After the institution of modern arsenical treatment, in 1910 and 1911, a number of cases of so-called arsphenamine jaundice were reported abroad. Since that time much literature has accumulated on this interesting phase of syphilis and its treatment.
More recently Wile and Sams discussed the subject thoroughly from the standpoint of 91 cases of syphilis of the liver and 56 cases of jaundice occurring during treatment at the University Hospital [Michigan] clinic. They found
LANE CG. JAUNDICE OCCURRING DURING THE TREATMENT OF SYPHILIS. Arch Derm Syphilol. 1939;39(2):278–293. doi:10.1001/archderm.1939.01480200085009
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