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Article
February 1939

FREI ANTIGEN PREPARED FROM MOUSE BRAIN

Arch Derm Syphilol. 1939;39(2):347-348. doi:10.1001/archderm.1939.01480200154015
Abstract

To the Editor:—  In their statement (Arch. Dermat. & Syph.38:383-388 [Sept.] 1938) that "the emulsion of mouse brain infected with the virus of lymphogranuloma venereum produced strongly positive reactions in all subjects known to have or have had lymphogranuloma venereum," Dr. Binkley and his associates have confirmed the results which Dr. Suskind and I1 have already published on the use of Frei antigen prepared from mouse brain. Since May 1934 we have performed 463 Frei tests with mouse brain antigen on 173 lymphogranulomatous subjects. All of the reactions were positive. There is no doubt, then, that this antigen yields a positive reaction in lymphogranulomatous subjects.Dr. Binkley and his associates further state that "in the control group of patients without lymphogranuloma, however, there was a high percentage of cases in which the emulsion of normal mouse brain produced a reaction." We have already observed this.1

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